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Gammaglobulin As Prophylaxis Against Rubella-Induced Congenital Anomalies

Department of Obstetrics and Gynecology, Hawaii Permanente Medical Group, Honolulu, Hawaii 96815 and Section on Infectious Diseases, Perinatal Research Branch, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20014.

Abstract

Low and high titered lots of gammaglobulin were tested for their value in preventing maternal and congenital rubella during the first 8 weeks of pregnancy. A total of 83 women who were exposed to rubella were each given 20 ml of gammaglobulin. No patient developed clinical rubella, 5 had seroconversions and none had infants with congenital rubella. Among 949 other pregnant women, 34.2% were susceptible, 6.7% had seroconversions and 1% had clinical rubella. Because of the low rates of rubella, there was no clear evidence that the incidence of maternal or congenital rubella was reduced by the use of gammaglobulin.