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Obstetrics & Gynecology 1972;39:173-181
© 1972 by The American College of Obstetricians and Gynecologists
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Reversible Vulvar Atypia

A Case Report

EDUARD G. FRIEDRICH, JR, MD

Department of Gynecology and Obstetrics, The Medical College of Wisconsin, Milwaukee, Wis 53226.

Abstract

A case of Bowenoid vulvar atypia occurring as a sequel to herpetic vulvitis was observed in a 15-year-old pregnant schoolgirl. The lesions consisted of multiple small papules. Type II herpes titer was positive although active virus was not isolated from the fresh tissue. Electron-microscopy revealed the presence of viral particles in the nuclei of the atypical cells. Postpartum, the lesions regressed spontaneously and were replaced by normal epithelium. Cellular atypicality, a reversible expression of the herpes-virus, was stimulated by the pregnant state, and underwent complete postpartum regression. A period of observation, prior to operation for carcinoma in situ of the vulva is warranted, especially in the younger age groups.




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