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Obstetrics & Gynecology 1970;35:671-675
© 1970 by The American College of Obstetricians and Gynecologists
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Estrogen-Induced Tubal Arrest of Ovum

Antagonism by Alpha Adrenergic Blockade

CARL J. PAUERSTEIN, MD, FACOG, B D FREMMING, DVM and JOSEPH E. MARTIN, MD

Departments of Obstetrics and Gynecology and of Laboratory Animal Medicine, The University of Texas Medical School at San Antonio

Abstract

The ability of appropriate doses of estradiol to arrest ovum passage through the rabbit oviduct has been well documented. The mechanism by which this "tube-locking" is effected has not been elucidated. This study was designed to examine possible interaction between estrogen and the intrinsic autonomic innervation of the oviductal isthmus. Blockade of the a adrenergic receptor with phenoxybenzamine significantly antagonized the arrest of ovum transport induced by estradiol






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