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Effect of Maternally Administered Magnesium Sulfate on the Neonate

From Obstetrics and Gynecology, The University of Texas (Southwestern) Medical School at Dallas and Parkland Memorial Hospital, Dallas, Tex.

Abstract

During a 14-year period, 7000 infants were born of mothers who had received magnesium sulfate parenterally because of preeclampsia or eclampsia. The serum level of magnesium of the fetus, although it rapidly approached that of the mother, could not be correlated with any ill effect. Magnesium sulfate was administered in intramuscular doses of 30-40 g during 24 hr to the gravida. This regimen was continued as long as she had demonstrable knee jerks, urine output of at least 100 ml during 4 hr, and no depression of respiration. No deleterious effect upon either fetus or newborn was noted.

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