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Obstetrics & Gynecology 1970;35:570-573
© 1970 by The American College of Obstetricians and Gynecologists
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Estriol Excretion with Erythroblastosis

BERNARD MANDELBAUM, MD, FACOG, MICHAEL ROSS, MD and TOMMY N. EVANS, MD, FACOG

From the Department of Gynecology and Obstetrics, Wayne State University School of Medicine, Detroit, Mich.

Abstract

Maternal urinary estriol determinations were performed in 48 patients with severe Rh isoimmunization. All fulfilled the criteria for prenatal transfusion. The test was found to be of prognostic and therapeutic significance only after 29 weeks' gestation. Traumatic fetal deaths from transfusion and survivors were easily distinguished on this basis from those destined to die of erythroblastosis. Depression of maternal urinary estriol excretion is associated with severe erythroblastosis. Low estriol levels are elevated when fetal survival occurs after prenatal transfusions.






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