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Microscopic Comparison of the Normal and Anencephalic Human Adrenal Gland with Emphasis on the Transient-Zone

From the Departments of Anatomy, Stanford University School of Medicine, Stanford, Calif, and the Ohio State University College of Medicine, Columbus, Ohio

Abstract

Developmental Stages 3, 4, and 5 of human adrenal glands from 14 anencephalic fetuses (16 weeks' gestation—term) and 28 normal glands from autopsy specimens (8.5 weeks' gestation—4 years) were microscopically compared. The time of disappearance of the transient- zone significantly differed in normal and anencephalic adrenal glands. At birth the anencephalic adrenal was markedly smaller than the normal, but its zonular development was comparable to that of a 2- to 4-year-old normal adrenal gland.

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