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Incidence and Prognosis of Endometrial Carcinoma by Histologic Grade and Extent

From the Institute of Pathology, Case Western Reserve University and University Hospitals of Cleveland, Ohio.

Abstract

In a review of 363 consecutive endometrial carcinomas during a 20-year period, the majority of endometrial neoplasms were observed to be well differentiated and confined to either the endometrium or the superficial half of the myometrium. An increased frequency of carcinomas limited to the endometrium was associated with a relative decrease in the number of more advanced neoplasms. The number of well differentiated endometrial carcinomas rose, and poorly differentiated neoplasms were less frequently encountered. The mean age at detection of endometrial carcinoma was 59.7 years. Less extensive well differentiated neoplasms were observed among younger women. The overall 5-year survival rate was 69.7%; length of survival was closely associated with anatomic extent of tumor and histologic grade. When extent and grade were collectively assessed in relation to 5-year survival, the biologic behavior of endometrial carcinoma was more accurately determined.