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Immunoreactive Insulin in Amniotic Fluid

From the Departments of Obstetrics and Gynecology, State University of New York, Downstate Medical Center, Brooklyn, NY, and the Long Island Jewish Medical Center-Queens Hospital Center Affiliation, Jamaica, NY.

Abstract

Immunoreactive insulin was found in amniotic fluid among 32 gravidas when pregnancy had advanced beyond the 16th week and when the fetus was alive. The concentrations were equivalent to or higher than fasting serum levels present in normal nonpregnant adults. No insulin was measurable in 1 patient at 16 weeks' gestation, a small quantity was found in another at 20 weeks, and increased concentrations thereafter. In 3 women in whom the fetus was dead, no insulin was present. Recovery experiments showed that insulin in amniotic fluid can be measured accurately by radioimmunoassay, even in the presence of meconium. Some variable changes in amniotic fluid insulin concentrations appeared to occur in response to maternal glucose loading.

This article has been cited by other articles:

				M. W. Carpenter, J. A. Canick, J. W. Hogan, C. Shellum, M. Somers, and J. A. Star Amniotic Fluid Insulin at 14-20 Weeks' Gestation: Association with later maternal glucose intolerance and birth macrosomia Diabetes Care, July 1, 2001; 24(7): 1259 - 1263. [Abstract] [Full Text] [PDF]