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Obstetrics & Gynecology 1970;35:381-388
© 1970 by The American College of Obstetricians and Gynecologists
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Histologic Study of the Uterine Cervix During Oral Contraception with Ethynodiol Diacetate and Mestranol

EMILIO CARBIA, MD, FACS, GUILLERMO RUBIO-LINARES, MD, ALBERTO ALVARADO-DURAN, MD and MARIO LOPEZ-LLERA, MD

From the Departments of Obstetrics and Gynecology and Pathology, Hospital de Gineco-Obstetricia del Centro Medico Nacional del Instituto Mexicano del Seguro Social, Mexico, DF.

Abstract

Colposcopically guided pre- and post-treatment cervical biopsies were made in 58 highly parous women, most of whom were more than 30 years of age, given an estrogen-progestogen contraceptive tablet for periods varying from 6 to 40 months. No precancerous changes were uncovered. The histopathologic alterations attributable to the use of the steroidal contraceptive agent were those of normal pregnancy. The cytologic and colposcopic findings were supportive of the histologic observations.






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