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Obstetrics & Gynecology 1970;35:358-363
© 1970 by The American College of Obstetricians and Gynecologists
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Significance of Mid-Zone Fluctuations in Amniotic Fluid Spectrophotometric Analysis for Rh-Isoimmunization

EMANUEL A. FRIEDMAN, MD, MedScD, FACOG*, ALLAN G. CHARLES, MD, FACOG and WILLIAM M. ALPERN, MD, FACOG

From the Department of Obstetrics and Gynecology. Michael Reese Hospital and Medical Center, Chicago, Ill.
*Department of Obstetrics and Gynecology, Harvard Medical School, Beth Israel Hospital, Boston, Mass.

Abstract

A total of 58 Rh-sensitized pregnancies with mid-zone spectral absorption peaks were studied to determine whether outcome could be prognosticated. Absolute levels were not clearly related to survival or severity of erythroblastosis fetalis, but relative trends were. Progressively rising peaks were associated with significantly higher perinatal mortality, more frequent and severe anemia, and greater need for exchange transfusions in the neonate. The more rapid the rise, the worse the outlook.






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