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Studies on Chemical Inhibition of the Rhesus Antigen-Antibody Reaction

From the Department of Obstetrics and Gynecology, University of Leeds, England

Abstract

Certain brain gangliosides are highly specific inhibitors of rhesus antibodies in vitro and useful guides to the structural and electrochemical requirements for effective inhibition. This proposition was examined with the of molecular models and a hypothetical inhibitor structure proposed. A range of chemical substances bearing some relation to the hypothetical inhibitor was tested for activity vitro and it was found that para-amino-salicylic acid, which bears the nearest resemblance, weak inhibitor of the rhesus antigen-antibody reaction under these conditions. However, hydration is shown to be at least as important as structural and electrochemical factors mode of action of rhesus inhibitors.