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Factor XI (PTA) Deficiency

Surgical and Obstetric Aspects

¹From the Department of Obstetrics and Gynecology, Columbia University, College of Physicians & Surgeons, Presbyterian Hospital, 622 W 168th St, New York, NY 10032
²From the Department of Medicine, Columbia University, College of Physicians & Surgeons, Presbyterian Hospital, 622 W 168th St, New York, NY 10032

Abstract

The potential postoperative hazard of undiagnosed and untreated severe Factor XI deficiency is described. The variability of overt symptoms and difficulties in arriving at specific diagnosis are emphasized. A program for preoperative screening and definitive factor testing, where indicated, is suggested. In therapy, on average, an infusion of 4.5 ml fresh frozen plasma per kilogram body weight will elevate Factor XI 10%. The half-life of infused Factor XI varies from 10 to 60 hr. Preoperative and antepartum prophylaxis in the severely Factor- Xl-deficient patient is advocated.