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Diagnosis and Treatment of Trophoblastic Disease

A Report from the Southeastern Regional Center

From the Department of Obstetrics and Gynecology, Duke University Medical Center, Southeastern Regional Trophoblastic Disease Center, Durham, NC 27706

Abstract

A review of the history of trophoblastic disease and its treatment and the assimilated experience of one of the regional centers is presented. The advent of single-agent chemotherapy raised the remission rate of nonmetastatic disease to 93% and of the metastatic form to 74%. Several new vigorous, initial therapeutic methods have been introduced at the SE Regional Center for patients who had developed resistance to all forms of single-agent therapy and for those with poor prognosis, as based upon prolonged duration of disease, high initial HCG titer, and cerebral or hepatic metastases.

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