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Stein-Leventhal Syndrome with Masculinizing Ovarian Tumors

Report of 3 Cases

From the Department of Gynecology and Obstetrics, The Marika Eliadi Maternity Hospital, Athens, Greece and the Department of Gynecology and Obstetrics, The Johns Hopkins University, School of Medicine and Hospital, Baltimore, Md.

Abstract

Three patients had Stein-Leventhal ovaries and masculinizing ovarian neoplasma—arrhenoblastoma, interstitial-cell tumor, and adrenal-rest tumor—at puberty. Since in animals androgenic substances at a critical period may produce changes similar to the histologic findings of the Stein-Leventhal syndrome, speculation arises as to whether the Stein-Leventhal syndrome in these girls was caused by the androgenic tumor.