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Anticoagulant Therapy During Pregnancy

A New Aproach

¹From the Surgical Coagulation Research Laboratory, Division of Surgery, Presbyterian-St. Luke's Hospital, affiliated with the College of Medicine, University of Illinois, Chicago, Ill.
*Present address: Chemistry Department, University of Waterloo, Waterloo, Ont, Canada

Abstract

The theoretical basis for a new approach to the use of anticoagulant therapy during pregnancy, embodying partial reduction of prothrombin levels, is described. In all, 14 patients who had a history of thromboembolism or developed an acute episode during pregnancy were carried through 16 pregnancies with such treatment. For 1 patient, a primipara, a 3-month-premature infant was delivered; it died 4 days later. Another patient developed a superficial thrombophlebitis during the postpartum period; she was the only patient in this series who did not receive complete anticoagulant therapy following delivery. There was no evidence of thromboembolism during or following 14 pregnancies. In 1 patient, thrombophlebitis developed shortly after conception and responded satisfactorily after institution of the new therapy. There was no evidence of abnormal bleeding in any of the mothers or infants, and all of the latter were normal.