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Obstetrics & Gynecology 1969;34:837-840
© 1969 by The American College of Obstetricians and Gynecologists
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Influence of Maternal Oophorectomy on the Collagen and Calcium Contents of Fetal Bone

RAJA W. ABDUL-KARIM, MD and LINDA D. MARSHALL, BA

From the Department of Obstetrics and Gynecology, State University of New York, Upstate Medical Center, Syracuse, NY

Abstract

The collagen and calcium contents of the femures of 31-day-old rabbit fetuses born to 3 groups of white New Zealand rabbits were measured. Rabbits in Group 1 were sham-operated and served as controls. Group 2 received MER-25 (ethamoxytriphetol), 25 mg/kg/day, plus progesterone, 3 mg/day, from Day 25-30 of gestation. Group 3 had bilateral oophorectomy on the Day 23 of gestation and received 5 mg of progesterone daily up to Day 31. The results show that there was a significant decrease in the collagen content in fetuses delivered to Groups 2 and 3, with no disturbance in calcification. These findings are discussed in relation to the influence of estrogens on endochondral bone formation in the rabbit fetus.






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