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Obstetrics & Gynecology 1969;34:792-798
© 1969 by The American College of Obstetricians and Gynecologists
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Pathology of the Placenta in Maternal Diabetes Mellitus

H. FOX, MD, MC Path

From the Department of Pathology, University of Manchester, England

Abstract

In the placentas of 48 diabetics, gross lesions were uncommon, but inconsistent abnormalities of villous maturation were common. Principal histologic abnormalities seen in the diabetic's placenta were an obliterative endarteritis of the fetal stem arteries, thickening of the trophoblastic basement membrane, and villous fibrinoid necrosis; all may result from immunologic damage. Villous fibrosis and excess syncytial knot formation were frequently observed; they are probably secondary to the fetal arterial abnormalities.







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