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Obstetrics & Gynecology 1969;34:215-220
© 1969 by The American College of Obstetricians and Gynecologists
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Maternal Death Associated with Excessive Ingestion of a Chlorothiazide Diuretic

Report of a Case

BARRY S. SCHIFRIN, MD*, WILLIAM N. SPELLACY, MD and WILLIAM A. LITTLE, MD, FACOG

From the Department of Obstetrics and Gynecology, University of Miami School of Medicine, Miami, Fla 33152
*Present Address: Yale University School of medicine, Department of Obstetrics and Gynecology, New Haven, Conn.

Abstract

The fatal illness of a gravida during the second trimester of pregnancy is described. It was characterized by coma, hyponatremia, hypokalemia, and hypochloremic alkalosis. Its onset was antedated by massive ingestion of a chlorothiazide diuretic during a 3-week period. Postmortem examination uncovered diffuse brain swelling, an alteration in keeping with the electrolyte imbalance present during the last few days of life.






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Copyright © 1969 by the American College of Obstetricians and Gynecologists.