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Obstetrics & Gynecology 1969;34:143-150
© 1969 by The American College of Obstetricians and Gynecologists
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Fetal Erythrocytes in Maternal Circulation of 155 Rh-Negative Women

ALAN E. BEER, MD

From the Department of Obstetrics and Gynecology and the William Pepper Laboratory of Clinical Medicine, University of Pennsylvania School of Medicine, Philadelphia

Abstract

One third of 144 Rh-negative unsensitized gravidas showed fetal erythrocytes during their third trimester of pregnancy. This was also true of more than half of 155 such women 1 hr after delivery of the placenta. Although manipulative removal of the placenta augments the occurrence of fetal-erythrocyte transfer, the number of such cells in the mother's circulation was not increased. Oxytocin-induced labor markedly increases transplacental passage of fetal red cells. Early postpartum injection of Rh-immune globulin clears Rh-incompatible fetal erythrocytes from the maternal blood and prevents primary isoimmunization.






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Copyright © 1969 by the American College of Obstetricians and Gynecologists.