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Ultrastructural Localization of Metabolic Enzymes During the Human Endometrial Cycle

* Present address: Department of Obstetrics and Gynecology, Kansai Medical School, Moriguchi, Osaka 570, Japan
From the Departments of Obstetrics and Gynecology, State University of New York, Downstate Medical Center, and University of Illinois at the Medical Center

Abstract

Specimens of human endometrium, obtained by biopsy daring each third of the proliferative phase and each day of the secretory phase, were dated by histologic criteria and studied histochemically with the aid of electron microscopy for the detection of three phosphatases. Alkaline phosphatase, identified on epithelial cell membranes but not in nuclei or stromal cells, was present throughout the proliferative phase and into the midsecretory phase. Acid phosphatase was observed in lysosomes of glandular epithelium after Cycle Day 21. Glucose-6-phosphatase, recognized for the first time in human endometrium, was most evident during the time of ovulation and early secretory phase. The timed localization of the enzymes suggests that they are biochemical determinants of the intracellular actions required to support implantation and early growth of the coNC.eptus.