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Fibrinolytic Activity of the Human Uterine Tube

From the James F. Mitchell Foundation, Institute for Medical Research, Washington, D. C, and the Department of Obstetrics and Gynecology, New York University School of Medicine, New York, N. Y.

SUMMARYFibrinolytic activity in human uterine tubes is caused by a plasminogen activator. No protease activity was observed. The concentration of plasminogen activator in the mucosal layer compared well with previously recorded assays of fibrinolytic human organs. The concentration in the muscular layer was exceedingly high, averaging from 1200 to 1700 U./gm. of fresh tissue. This is the highest average concentration in any human tissues so far recorded. Individual specimens reached even 5000 U./gm. The concentration in the serosal layer was high (700–1000 U.), in some cases approaching the concentration in the muscularis. There were no significant differences between the distal, medial, and proximal sections of the tubes.