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Obstetrics & Gynecology 2007;110:1231-1236
© 2007 by The American College of Obstetricians and Gynecologists
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ORIGINAL RESEARCH

Association of Elevated C-reactive Protein Levels With an Impaired Prognosis in Patients With Surgically Treated Endometrial Cancer

Maximilian Schmid, MD1, Alois Schneitter, MD2, Stefan Hinterberger, MD3, Julia Seeber2, Alexander Reinthaller, MD1 and Lukas Hefler, MD1

From the Departments of Obstetrics & Gynecology, 1 Medical University of Vienna, Vienna, Austria; 2 Innsbruck Medical University, Innsbruck, Austria; and 3 Landeskrankenhaus Klagenfurt, Klagenfurt, Austria.

OBJECTIVE: To evaluate whether C-reactive protein (CRP) serum levels are associated with prognosis in surgically treated endometrial cancer.

METHODS: In the present multicenter study, CRP serum levels were measured preoperatively in 403 surgically staged patients with endometrioid endometrial cancer. Results were correlated to clinical data.

RESULTS: The mean (standard deviation) serum CRP level in patients with endometrial cancer was 1.0 (1.8) mg/dL. Serum CRP levels were associated with tumor stage (P=.01), but not with tumor grade (P=.8), lymph node involvement (P=.8), and age at diagnosis (P=.9). In a univariable survival analysis, serum CRP levels, tumor stage, tumor grade, and age at diagnosis were associated with disease-free and overall survival (all P <.001). In a multivariable Cox regression model, serum CRP levels (P=.001, P=.004), tumor stage (P <.001, P <.001), tumor grade (P=.02, P=.009), and age at diagnosis (P=.002, P=.001) were independent prognostic factors for disease-free and overall survival.

CONCLUSION: Our results suggest that elevated serum CRP levels are associated with a less favorable prognosis in patients with surgically treated endometrial cancer.

LEVEL OF EVIDENCE: II






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