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Obstetrics & Gynecology 2007;110:788-792
© 2007 by The American College of Obstetricians and Gynecologists
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ORIGINAL ARTICLES

Serotonin Receptor 1A C(-1019)G Polymorphism Associated With Premenstrual Dysphoric Disorder

Vandana Dhingra, MBBS1, Julia L. Magnay, MSc, CSci2, P. M. Shaughn O'Brien, MD, FRCOG1,2, Gail Chapman, MPhil1, Anthony A. Fryer, PhD2,3 and Khaled M. K. Ismail, MD, MRCOG1,2

From the 1Academic Unit of Obstetrics and Gynecology, Keele University Medical School, University Hospital of North Staffordshire; 2Institute for Science and Technology in Medicine, Keele University, Hartshill Campus; and 3Department of Biochemistry, Central Pathology Laboratory, University Hospital of North Staffordshire, Stoke on Trent, United Kingdom.

ABSTRACT

OBJECTIVE: To assess whether the G allele of the serotonin receptor 1A C(-1019)G polymorphism is associated with premenstrual dysphoric disorder.

METHODS: The study sample comprised 53 women with clinically diagnosed premenstrual dysphoric disorder (age range 27–46 years, mean 37.7 years) and 51 healthy control subjects (age range 22–48 years, mean 36.2 years). The serotonin receptor 1A C(-1019)G polymorphism was genotyped and compared between the two groups.

RESULTS: In contrast to the postulated "high-risk" G/G genotype, there was a marked overrepresentation of the C/C genotype in the premenstrual dysphoric disorder group (P=.034; odds ratio 3.63, 95% confidence interval 1.22–10.78). The presence of at least one C allele was associated with a 2.5-fold increased risk of premenstrual dysphoric disorder (P=.053; odds ratio 2.46, 95% confidence interval 1.03–5.88).

CONCLUSION: Our hypothesis that the high-risk G allele is associated with the occurrence of premenstrual dysphoria was not proved in this study. However, due to the increased prevalence of the C variant, we suggest that the C(-1019) allele may contribute to the risk of premenstrual dysphoria.

LEVEL OF EVIDENCE: II






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