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Obstetrics & Gynecology 2007;109:806-812
© 2007 by The American College of Obstetricians and Gynecologists
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ORIGINAL RESEARCH

Development of a Nomogram for Prediction of Vaginal Birth After Cesarean Delivery

William A. Grobman, MD, MBA1, Yinglei Lai, PhD2, Mark B. Landon, MD3, Catherine Y. Spong, MD4, Kenneth J. Leveno, MD5, Dwight J. Rouse, MD, MSPH6, Michael W. Varner, MD7, Atef H. Moawad, MD8, Steve N. Caritis, MD9, Margaret Harper, MD10, Ronald J. Wapner, MD11, Yoram Sorokin, MD12, Menachem Miodovnik, MD13,14, Marshall Carpenter, MD15, Mary J. O'Sullivan, MD16, Baha M. Sibai, MD17, Oded Langer, MD18, John M. Thorp, MD19, Susan M. Ramin, MD20, Brian M. Mercer, MD21 for the National Institute of Child Health and Human Development (NICHD) Maternal–Fetal Medicine Units Network (MFMU)*

From the Departments of Obstetrics and Gynecology at 1Northwestern University, Chicago, Illinois; 2the George Washington University Biostatistics Center, Washington, DC; 3the Ohio State University, Columbus, Ohio; 4National Institute of Child Health and Human Development, Bethesda, Maryland; 5University of Texas Southwestern Medical Center, Dallas, Texas; 6University of Alabama at Birmingham, Birmingham, Alabama; 7University of Chicago, Chicago, Illinois; 8University of Utah, Salt Lake City, Utah; 9University of Pittsburgh, Pittsburgh, Pennsylvania; 10Wake Forest University, Winston-Salem, North Carolina; 11Thomas Jefferson University, Philadelphia, Pennsylvania; 12Wayne State University, Detroit, Michigan; 13University of Cincinnati, Cincinnati, Ohio; 14Columbia University, New York, New York; 15Brown University, Providence, Rhode Island; 16University of Miami, Miami, Florida; 17University of Tennessee, Memphis, Tennessee; 18University of Texas at San Antonio, San Antonio, Texas; 19University of North Carolina, Chapel Hill, North Carolina; 20University of Texas at Houston, Houston, Texas; and 21Case Western Reserve University, Cleveland, Ohio.

OBJECTIVE: To develop a model based on factors available at the first prenatal visit that predicts chance of successful vaginal birth after cesarean delivery (VBAC) for individual patients who undergo a trial of labor.

METHODS: All women with one prior low transverse cesarean who underwent a trial of labor at term with a vertex singleton gestation were identified from a concurrently collected database of deliveries at 19 academic centers during a 4-year period. Using factors identifiable at the first prenatal visit, we analyzed different classification techniques in an effort to develop a meaningful prediction model for VBAC success. After development and cross-validation, this model was represented by a graphic nomogram.

RESULTS: Seven-thousand six hundred sixty women were available for analysis. The prediction model is based on a multivariable logistic regression, including the variables of maternal age, body mass index, ethnicity, prior vaginal delivery, the occurrence of a VBAC, and a potentially recurrent indication for the cesarean delivery. After analyzing the model with cross-validation techniques, it was found to be both accurate and discriminating.

CONCLUSION: A predictive nomogram, which incorporates six variables easily ascertainable at the first prenatal visit, has been developed that allows the determination of a patient-specific chance for successful VBAC for those women who undertake trial of labor.

LEVEL OF EVIDENCE: II




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