HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Soares, C. N. Articles by Cohen, L. Search for Related Content PubMed PubMed Citation Articles by Soares, C. N. Articles by Cohen, L. Related Collections Menopause and HRT Reproductive endocrinology

Eszopiclone in Patients With Insomnia During Perimenopause and Early Postmenopause

A Randomized Controlled Trial

From ¹the Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada; ²Department of Psychiatry, Harvard Medical School, Boston, Massachusetts; ³Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts; ⁴Sepracor Inc., Marlborough, Massachusetts; ⁵Department of Psychiatry and Behavioral Neurosciences, Henry Ford Hospital Sleep Center, Detroit, Michigan.

OBJECTIVE: To evaluate eszopiclone 3 mg for treatment of insomnia in perimenopausal and early postmenopausal women, as well as the impact of insomnia treatment on mood, menopause-related symptoms, and quality of life.

METHODS: This was a double-blind, placebo-controlled study with 410 women (aged 40–60; perimenopausal or early postmenopausal) who reported insomnia defined as sleep latency of at least 45 minutes and total sleep time less than or equal to 6 hours per night for at least 3 nights per week over the previous month. Patients were randomly assigned to eszopiclone 3 mg or placebo nightly for 4 weeks. Sleep data were collected once a day. Physician global assessments of menopause, menopause-specific questionnaire, Greene Climacteric Scale, the Montgomery Asberg Depression Rating Scale, and the Sheehan Disability Scale were collected at baseline and end of treatment.

RESULTS: Patients receiving eszopiclone reported improvements in sleep induction, sleep maintenance, sleep duration, sleep quality, and next-day functioning relative to placebo (P<.05). Patients receiving eszopiclone reported fewer total awakenings and awakenings due to hot flushes (P<.05). Eszopiclone use led to greater improvement in Montgomery Asberg Depression Rating Scale scores (P<.05) and physician global assessments of menopause scores (P<.001); total Greene Climacteric Scale score and the vasomotor and psychological sub-scores (P<.05); vasomotor and physical domains of the menopause-specific questionnaire (P<.05); and family life/home domain of the Sheehan Disability Scale (P<.05).

CONCLUSION: In this study, eszopiclone provided significant improvements in sleep and positively impacted mood, quality of life, and menopause-related symptoms in perimenopausal and early postmenopausal women with insomnia.

CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov www.clinicaltrials.gov NCT00366093

LEVEL OF EVIDENCE: I

This article has been cited by other articles:

				M. Pollack, G. Kinrys, A. Krystal, W. V. McCall, T. Roth, K. Schaefer, R. Rubens, J. Roach, H. Huang, and R. Krishnan Eszopiclone Coadministered With Escitalopram in Patients With Insomnia and Comorbid Generalized Anxiety Disorder Arch Gen Psychiatry, May 1, 2008; 65(5): 551 - 562. [Abstract] [Full Text] [PDF]