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Obstetrics & Gynecology 2006;107:263-268
© 2006 by The American College of Obstetricians and Gynecologists
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ORIGINAL RESEARCH

Humidified Compared With Dry, Heated Carbon Dioxide at Laparoscopy to Reduce Pain

Todd M. Beste, MD1, James A. Daucher, MD2 and Donald Holbert, PhD3

From the 1Division of General Obstetrics and Gynecology, Department of Obstetrics and Gynecology, East Carolina University Brody School of Medicine; 2Department of Obstetrics and Gynecology, University Health Systems/Pitt County Memorial Hospital, East Carolina University Brody School of Medicine; and 3Department of Biostatistics, East Carolina University, Greenville, North Carolina.

OBJECTIVE: To study whether using 95% humidified, heated carbon dioxide (CO2) at laparoscopy reduces pain compared with dry, heated CO2.

METHODS: Patients were randomly assigned to either heated, 95% humidified CO2 (study group) or heated, dry CO2 (control group) during laparoscopy. Pain control was achieved per standard protocols. Pain scales were administered the first 4 hours and 24 and 48 hours postoperatively.

RESULTS: The 89 patients available in the intent-to-treat model revealed a decrease in total morphine equivalents and a decrease in pain scores at 1, 2, and 24 hours in the study group (directional P values < .05). Subgroup analysis in patients without chronic pelvic pain revealed lower mean pain scores at 1, 2, 24, and 48 hours and decreases in postoperative and total morphine equivalents (directional P values < .05) in the study group.

CONCLUSION: At laparoscopy, heated, 95% humidified CO2 effectively decreases postoperative pain and narcotics usage compared with heated, dry CO2.

LEVEL OF EVIDENCE: II-2






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