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Obstetrics & Gynecology 2005;106:1196-1199
© 2005 by The American College of Obstetricians and Gynecologists
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CASE REPORTS

Goodpasture Syndrome in a Pregnant Woman

D. Marie Vasiliou, MSc, MD1, Cynthia Maxwell, MD, FRCSC2, Prakeshkumar Shah, MD, MRCP3 and Mathew Sermer, MD, FRCSC2

From the 1Department of Medicine; 2Department of Obstetrics and Gynaecology, Division of Maternal Fetal Medicine; and 3Department of Paediatrics, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

BACKGROUND: Goodpasture syndrome, an immunologic disorder characterized by glomerulonephritis and pulmonary hemorrhage, rarely presents in pregnancy.

CASE: We describe a patient who was diagnosed with Goodpasture syndrome in her second trimester. She required daily hemodialysis, intermittent plasmapheresis, and immunosuppressive therapy. Her pregnancy was complicated by hypertension, and she delivered a low birth weight neonate prematurely at 26 4/7 weeks of gestation by cesarean due to nonreassuring fetal status. Deterioration in the fetal status may have been secondary to complications of hypertension, in addition to prematurity.

CONCLUSION: Goodpasture syndrome in pregnancy may be associated with significant maternal and fetal morbidity.






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