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Obstetrics & Gynecology 2005;106:1187-1189
© 2005 by The American College of Obstetricians and Gynecologists
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CASE REPORTS

Herpes Simplex Virus Hepatitis Causing Acute Liver Dysfunction and Thrombocytopenia in Pregnancy

Rebecca H. Allen, MD, MPH1 and Ruth E. Tuomala, MD2

From the 1Department of Obstetrics and Gynecology, Brigham and Women’s Hospital and Massachusetts General Hospital; and the 2Department of Obstetrics and Gynecology, Division of Maternal–Fetal Medicine, Brigham and Women’s Hospital, Boston Massachusetts.

BACKGROUND: Herpes simplex virus (HSV) hepatitis in pregnant women is a rare condition. We report a case confirmed by liver biopsy and successfully treated with empiric intravenous acyclovir.

CASE: A 25-year-old primigravida at 34 weeks of gestation presented with fever, thrombocytopenia, and markedly elevated liver enzymes. The patient was treated empirically and was delivered by cesarean. After delivery failed to correct her condition, a liver biopsy revealed HSV hepatitis. The fetus was unaffected and the patient recovered with an extended course of acyclovir.

CONCLUSION: Pregnant women are susceptible to disseminated HSV causing hepatitis. A high index of suspicion is necessary to diagnose HSV hepatitis and begin appropriate treatment with acyclovir. Herpes simplex virus hepatitis should be included in the differential diagnosis for liver failure during pregnancy.




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