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Obstetrics & Gynecology 2005;106:1180-1182
© 2005 by The American College of Obstetricians and Gynecologists
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CASE REPORTS

Severe Hemolytic Disease of the Newborn Due to Anti-Cw

Benjamin D. Byers, DO1, Michael C. Gordon, MD1 and Kenneth Higby, MD1

From the 1San Antonio Uniformed Services Health Education Consortium, Brooke Army Medical Center and Wilford Hall United States Air Force Medical Center, San Antonio, Texas.

BACKGROUND: Pregnancies complicated by Rh isoimmunization have decreased significantly since the widespread use of Rh immune globulin. Uncommon red blood cell antigens have therefore become more clinically evident. We report a case of anti-Cw immunization that resulted in severe fetal anemia that required multiple transfusions.

CASE: A 28-year-old multigravida presented to our service at 18 weeks of gestation with her fourth pregnancy. Her pregnancy was complicated by anti-Cw isoimmunization that resulted in severe fetal anemia requiring in utero fetal blood transfusions.

CONCLUSION: While previous reports recommend only postpartum surveillance when Cw isoimmunization is present, we report a case resulting in severe fetal anemia.






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