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CASE REPORTS |
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan
BACKGROUND: Enlarged multicystic ovaries and an elevated estradiol (E2) concentration have been reported as characteristics of follicle stimulating hormone (FSH)-secreting adenomas in reproductive-aged women. The natural course of the hormone in relationship to the microadenoma and ovarian findings, however, remains largely unknown.
CASE: A 40-year-old woman with enlarged multicystic ovaries was nonsurgically diagnosed with an FSH-producing pituitary microadenoma. During her subsequent 12-month follow-up, the serum concentration of E2, but not FSH, and the size of the multicystic ovaries fluctuated dramatically. Both the E2 level and ovarian size were transiently normalized.
CONCLUSION: Because of disease-related fluctuations, a reproductive-aged woman with an FSH-producing adenoma did not always present with laboratory values characteristic of ovarian hyperstimulation. This finding points out a possible pitfall in diagnosis and clinical management.
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T. Kajitani, S. Liu, T. Maruyama, H. Uchida, R. Sakurai, H. Masuda, T. Nagashima, M. Ono, T. Arase, and Y. Yoshimura Analysis of serum FSH bioactivity in a patient with an FSH-secreting pituitary microadenoma and multicystic ovaries: A case report Hum. Reprod., February 1, 2008; 23(2): 435 - 439. [Abstract] [Full Text] [PDF] |
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