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Obstetrics & Gynecology 2005;105:61-66
© 2005 by The American College of Obstetricians and Gynecologists
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ORIGINAL RESEARCH

Age and the Prevalence of Bleeding Disorders in Women With Menorrhagia

Claire S. Philipp, MD, Ambarina Faiz, MD, MPH, Nicole Dowling, PhD, Anne Dilley, PhD*, Lisa A. Michaels, MD, Charletta Ayers, MD, MPH, Connie H. Miller, PhD, Gloria Bachmann, MD, Bruce Evatt, MD and Parvin Saidi, MD

From the Departments of Medicine, Pediatrics, and Obstetrics and Gynecology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey; and Center for Birth Defects, Centers for Disease Control and Prevention, Atlanta, Georgia.

Address reprint requests to: Claire Philipp, MD, Division of Hematology, MEB Rm 578, 1 Robert Wood Johnson Place, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ 08903; e-mail: philipp{at}umdnj.edu.

OBJECTIVE: A study was conducted to evaluate the frequency and types of hemostatic defects occurring in adolescent and perimenopausal-age women diagnosed with menorrhagia.

METHODS: A total of 115 women with a physician diagnosis of menorrhagia, including 25 adolescent women, 25 perimenopausal-age women, and 65 women between the ages of 20 and 44, underwent comprehensive hemostatic testing for possible bleeding disorders. Frequencies of bleeding disorders were calculated and compared.

RESULTS: Forty-seven percent of women were found to have hemostatic abnormalities, including platelet dysfunction, von Willebrand’s disease, and coagulation factor deficiencies. Adolescents and perimenopausal-age women with menorrhagia were just as likely to have hemostatic abnormalities as were women aged 20 to 44.

CONCLUSION: These results demonstrate that underlying bleeding disorders are frequently found in adolescent, postadolescent reproductive age, and perimenopausal-age women presenting with menorrhagia and suggest that women with menorrhagia should be considered for further hemostatic evaluation.

LEVEL OF EVIDENCE: II-2




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