HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Trimble, C. L. Articles by Alberg, A. J. Search for Related Content PubMed PubMed Citation Articles by Trimble, C. L. Articles by Alberg, A. J. Related Collections Epidemiology/public health

Active and Passive Cigarette Smoking and the Risk of Cervical Neoplasia

Cornelia L. Trimble, MD^*, Jeanine M. Genkinger, PhD, MHS, Alyce E. Burke, MPH, Sandra C. Hoffman, MPH, Kathy J. Helzlsouer, MD, MHS, Marie Diener-West, PhD, George W. Comstock, MD, DrPH and Anthony J. Alberg, PhD, MPH

From the *Department of Obstetrics and Gynecology, The Johns Hopkins School of Medicine, and Departments of Epidemiology and Biostatistics, the Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Address reprint requests to: Anthony J. Alberg, Department of Epidemiology, Room E6132B, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205; e-mail: aalberg{at}jhsph.edu.

OBJECTIVE: Evidence links active cigarette smoking to cervical neoplasia, but much less is known about the role of passive smoking. Using a prospective cohort design, we examined personal cigarette smoking and household passive smoke exposure in relation to the risk of cervical neoplasia.

METHODS: Cohorts were established based on data collected on the smoking status of all household members during private censuses of Washington County, Maryland in 1963 (n = 24,792) and 1975 (n = 26,381). Using the Washington County Cancer Registry, the occurrence of cervical neoplasia in the two cohorts was ascertained from 1963–1978 and from 1975–1994. Poisson regression models were fitted to estimate the relative risk of developing cervical neoplasia associated with active and passive smoking in both cohorts. The referent category for all comparisons was never smokers not exposed to passive smoking.

RESULTS: The adjusted relative risk and 95% confidence limits for passive smoking was 2.1 (1.3, 3.3) in the 1963 cohort and 1.4 (0.8, 2.4) in the 1975 cohort. The adjusted relative risk and 95% confidence limits for current smoking were 2.6 (1.7, 4.1) and 1.7 (1.1, 2.6) in the 1963 and 1975 cohort, respectively.

CONCLUSION: The associations were in the direction of increased risk for both passive smoking and current active smoking in both the 1963 and 1975 cohorts, but were stronger in the 1963 cohort. The results of this long-term, prospective cohort study corroborate the association between active cigarette smoking and cervical neoplasia and provide evidence that passive smoking is a risk factor for cervical neoplasia.

LEVEL OF EVIDENCE: II-2

This article has been cited by other articles:

				J. Mock, S. J. McPhee, T. Nguyen, C. Wong, H. Doan, K. Q. Lai, K. H. Nguyen, T. T. Nguyen, and N. Bui-Tong Effective Lay Health Worker Outreach and Media-Based Education for Promoting Cervical Cancer Screening Among Vietnamese American Women Am J Public Health, September 1, 2007; 97(9): 1693 - 1700. [Abstract] [Full Text] [PDF]

				A. J. Alberg, A. Kouzis, J. M. Genkinger, L. Gallicchio, A. E. Burke, S. C. Hoffman, M. Diener-West, K. J. Helzlsouer, and G. W. Comstock A Prospective Cohort Study of Bladder Cancer Risk in Relation to Active Cigarette Smoking and Household Exposure to Secondhand Cigarette Smoke Am. J. Epidemiol., March 15, 2007; 165(6): 660 - 666. [Abstract] [Full Text] [PDF]

				Even Passive Cigarette Smoking Is Associated with Cervical Neoplasia Journal Watch (General), February 1, 2005; 2005(201): 6 - 6. [Full Text]