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Severe Acute Respiratory Syndrome in Pregnancy

Mark H. Yudin, MD, MSc^*¶, Donna M. Steele, MD^*¶, Michael D. Sgro, MD^¶, Stanley E. Read, MD^||, Peter Kopplin, MD^¶ and Kevin A. Gough, MD^¶

Departments of *Obstetrics and Gynecology, Pediatrics, and Internal Medicine, Divisions of Infectious Diseases, ¶St. Michael's Hospital, ||The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

Address reprint requests to: Mark H. Yudin, MD, St. Michael's Hospital, Department of Obstetrics and Gynecology, 61 Queen Street East, 5th Floor, Toronto, Ontario, M5C 2T2, Canada; e-mail: yudinm{at}smh.Toronto.on.ca.

BACKGROUND: There is limited worldwide experience with severe acute respiratory syndrome (SARS) in pregnancy. We present a case of SARS complicating pregnancy in the third trimester, with outcome data on both the mother and baby.

CASE: A 33-year-old gravida 2 para 1 fulfilling the World Health Organization case definition for probable SARS was admitted to our institution at 31 weeks of gestation with fever, a dry cough, and patchy infiltrates on chest X-ray. The patient was previously healthy and acquired SARS from close contact with an infected family member. Convalescent serology results were positive for antibodies to coronavirus. She stayed in hospital for 21 days and did not require intensive care admission or ventilatory support. Labor occurred spontaneously at term, and a healthy female baby was delivered with no evidence of infection.

CONCLUSION: Severe acute respiratory syndrome in pregnancy is a potentially life-threatening illness with complicated management issues. Hospitalization and care by a multidisciplinary team may optimize chances for a good outcome.

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