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Obstetrics & Gynecology 2004;104:1144-1147
© 2004 by The American College of Obstetricians and Gynecologists
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CASE REPORTS

Amyloidosis of the Endometrium: An Asymptomatic Presentation

Danielle D. Winkler, MD*, Jacqueline A. Emery, MD{dagger} and Carol B. Alan, MD*

*Department of Obstetrics and Gynecology and {dagger}Department of Pathology, University of South Carolina and Palmetto Richland Memorial Hospital, Columbia, South Carolina

Address reprint requests to: Danielle D. Winkler, md, Department of Obstetrics and Gynecology, University of South Carolina, 2 Medical Park, Suite 208, Columbia, SC 29203; e-mail: ddwinkler{at}att.net.

BACKGROUND: Amyloidosis of the endometrium is a rare occurrence according to current literature. Previously reported cases have presented with menorrhagia or postmenopausal bleeding.

CASE: A postmenopausal woman with multiple medical problems presented with fatigue and weight loss. During the evaluation for her 18-kg weight loss, a computed tomography scan revealed an enlarged uterus and liver lesions. Endometrial and liver biopsies were performed secondary to concern over metastatic cancer, given an enlarged uterus in a postmenopausal woman with liver masses. She was found to have systemic primary amyloidosis in multiple organs, including her endometrium.

CONCLUSION: This patient represents an interesting case of systemic amyloidosis involving the endometrium that is not associated with vaginal bleeding. The presence of amyloid in the endometrium may be more common than currently recognized, because patients without vaginal bleeding are not routinely evaluated for amyloid deposition in their reproductive organs.






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