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Immature Ovarian Teratoma With Hyponatremia and Low Antidiuretic Hormone Level

Horace Roman, MD^*, Eric Verspyck, PhD, Loïc Sentilhes, MD and Georges Barau, MD^*

*Department of Gynecology and Obstetrics, Groupe Hospitalier Sud Réunion, St. Pierre, Reunion Island, France; and Department of Gynecology and Obstetrics, University Hospital of Rouen, France

Address reprint requests to: Horace Roman, MD, Department of Obstetrics and Gynecology, Rouen University Hospital-Charles Nicolle, 76031 Rouen Cedex, France; e-mail: horace.roman{at}libertysurf.fr.

BACKGROUND: Inappropriate antidiuretic hormone secretion syndrome is rare in patients with gynecologic tumors.

CASE: A 22-year-old woman presented with inappropriate antidiuretic hormone secretion symptoms during the 2 months preceding the diagnosis of an immature ovarian teratoma. Vasopressin levels in serum and in the urine were very low. Restriction of water intake and surgical removal of the teratoma resulted in the definitive correction of the hyponatremia. This observation suggests that immature teratoma cells can produce a vasopressin-like factor, and the syndrome may be a sign of an ovarian malignancy.

CONCLUSION: Pelvic organs should be examined when the more common causes of inappropriate antidiuretic hormone secretion syndrome have been ruled out.