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Obstetrics & Gynecology 2004;103:1094-1096
© 2004 by The American College of Obstetricians and Gynecologists
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CASE REPORTS

Tumor-Level Serum Testosterone Associated With Human Immunodeficiency Virus Lipodystrophy Syndrome

Michael H. Dahan, MD*, Larry N. Lyle, DO{dagger}, Ada Wolfsen, MD{ddagger} and R Jeffrey Chang, MD§

*Department of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, Missouri; {dagger}Scripps Mercy Hospital, San Diego, California; {ddagger}Department of Medical Education, Scripps Mercy Hospital, San Diego, California; and §Department of Reproductive Medicine, The University of California at San Diego, La Jolla, California

Address reprint requests to: Michael H. Dahan, MD, Division of Reproductive Endocrinology, Washington University in St. Louis, 4444 Forest Park Avenue, St. Louis, MO 63108-2259; e-mail: dahanhaim{at}hotmail.com.

BACKGROUND: Human immunodeficiency virus (HIV) lipodystrophy syndrome consists of insulin resistance, hyperlipidemia, increased waist-to-hip ratios, and relative hyperandrogenemia, which resembles polycystic ovary syndrome.

CASE: A 30-year-old HIV-positive multipara with lipodystrophy syndrome had an elevated level of serum total testosterone (244 ng/dL) in the tumor range.

CONCLUSION: In HIV lipodystrophy syndrome, marked elevations of total serum testosterone in the range reserved for androgen-producing tumors may occur. The elevated testosterone levels are derived from the ovary and are responsive to gonadotropin suppression.






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