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ORIGINAL RESEARCH |
From the Center for Perinatal, Pediatric and Environmental Epidemiology of the Department of Epidemiology and Public Health and Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut;Department of Epidemiology, University of Iowa College of Public Health, Iowa City, Iowa; and Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Address reprint requests to: Michael Bracken, Yale University School of Medicine, 60 College Street, PO Box 208034, New Haven, CT 06520-8034; E-mail: michael.bracken{at}yale.edu.
OBJECTIVE: To prospectively examine in pregnant women whether asthma or asthma therapy influenced preterm delivery, intrauterine grown restriction (IUGR), or birthweight.
METHODS: We enrolled 873 pregnant women with a history of asthma, of whom 778 experienced asthma symptoms or took medication, and 1333 women with no asthma history, including 884 women with neither asthma diagnosis nor symptoms and 449 with symptoms but no diagnosis. Asthma symptoms, medication, and severity were classified according to 2002 Global Initiative for Asthma guidelines.
RESULTS: Preterm delivery was not associated with asthma diagnosis, severity, or symptoms but was associated with use of controller medications, independent of symptoms, specifically oral steroids and theophylline. Gestation was reduced by 2.22 weeks in women using oral steroids daily (P = .001) and 1.11 weeks after theophylline (P = .002). We observed a 24% (5–47%) increased risk for IUGR with each increased symptom step, which increased further in symptomatic women with no asthma diagnosis (31%, 4–65%) compared with women with neither asthma nor symptoms.
CONCLUSION: We found no effect of asthma symptoms or severity on preterm delivery but observed increased risks associated with use of oral steroid and theophylline. Intrauterine growth restriction was associated with asthma severity, which possibly reflects a hypoxic fetal effect. Women with asthma symptoms but no diagnosis were at particular risk of undermedication and delivering IUGR infants. These observations support guidelines that advocate active management of pregnant patients with mild or moderate asthma with ß2 agonists, with oral steroids added only if severity increases. Symptomatic patients without an asthma diagnosis might need to be equally managed.
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