| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
ORIGINAL RESEARCH |
From the Department of Obstetrics and Gynaecology, Northwick Park and St. Mark’s Hospital, London; Imperial College School of Medicine, London; Department of Obstetrics and Gynaecology, Jessops Hospital for Women, Sheffield; and Manchester Centre for Sexual Health, Manchester Royal Infirmary, Manchester, United Kingdom.
Address reprint requests to: Ronald F. Lamont, DM, FRCOG, Northwick Park and St. Mark’s Hospital, Department of Obstetrics & Gynaecology, Watford Road, Harrow, Middlesex, London, HA1 3UJ, United Kingdom; E-mail: pauline.mills{at}nwlh.nhs.uk.
OBJECTIVE: To assess the ability of clindamycin vaginal cream to reduce the incidence of preterm birth in women with abnormal genital tract flora in the second trimester of pregnancy.
METHODS: This was a randomized, double-blind, placebo-controlled, tricenter study. A total of 409 women with abnormal genital tract flora on Gram stain of vaginal secretions at 13–20 weeks’ gestation were randomized to receive a 3-day course of clindamycin vaginal cream or placebo. Those women who still had abnormal vaginal flora 3 weeks later received a 7-day course of the original study drug (ie, either clindamycin vaginal cream or placebo as per original randomization). The primary outcome measure was the incidence of preterm birth.
RESULTS: There was a statistically significant reduction in the incidence of preterm birth in the clindamycin vaginal cream group (4%) compared with placebo (10%) (P < .03). Significantly more babies born preterm (63%) required admission to the neonatal intensive care unit compared with term infants (4%) (P < .001).
CONCLUSION: A 2% clindamycin vaginal cream, when compared with placebo administered to women with abnormal genital tract flora before 20 weeks’ gestation, can reduce the incidence of preterm birth by 60% and hence the need for neonatal intensive care.
This article has been cited by other articles:
|
|
 |
|
  P. Nygren, R. Fu, M. Freeman, C. Bougatsos, M. Klebanoff, and J.-M. Guise Evidence on the Benefits and Harms of Screening and Treating Pregnant Women Who Are Asymptomatic for Bacterial Vaginosis: An Update Review for the U.S. Preventive Services Task Force Ann Intern Med, February 5, 2008; 148(3): 220 - 233. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Chatterjee, J. Gullam, M. Vatish, and S. Thornton The management of preterm labour Arch. Dis. Child. Fetal Neonatal Ed., March 1, 2007; 92(2): F88 - F93. [Full Text] [PDF]
|
|
|
|
 |
|
 L. O. Eckert Acute Vulvovaginitis N. Engl. J. Med., September 21, 2006; 355(12): 1244 - 1252. [Full Text] [PDF]
|
|
|
|
 |
|
 N. Okun, K. A. Gronau, and M. E. Hannah Antibiotics for Bacterial Vaginosis or Trichomonas vaginalis in Pregnancy: A Systematic Review Obstet. Gynecol., April 1, 2005; 105(4): 857 - 868. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kiss, L. Petricevic, and P. Husslein Prospective randomised controlled trial of an infection screening programme to reduce the rate of preterm delivery BMJ, August 14, 2004; 329(7462): 371. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ugwumadu, F. Reid, P. Hay, and I. Manyonda Natural History of Bacterial Vaginosis and Intermediate Flora in Pregnancy and Effect of Oral Clindamycin Obstet. Gynecol., July 1, 2004; 104(1): 114 - 119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Early Clindamycin Might Reduce Preterm Birth Journal Watch (General), April 25, 2003; 2003(425): 4 - 4. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
