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ORIGINAL RESEARCH |
From the Department of Obstetrics and Gynecology, HUCH, Jorvi Hospital, Espoo; Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki; and Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland.
Address reprint requests to: Pekka Taipale, MD, PhD, Kuopio University Hospital, Department of Obstetrics and Gynecology, PL 1777, 70211 Kuopio, Finland; E-mail: pekka.taipale{at}kuh.fi.
OBJECTIVE: To assess the value of first trimester screening by ultrasonography in detecting structural anomalies of the fetus in a general obstetric population.
METHODS: During 19931998, 20,465 consecutive pregnant women who resided in a defined geographic area participated in ultrasonographic screening for major malformations. These included anomalies of the central nervous system, urinary tract, abdominal wall, and long bones. Heart anomalies were not expected to be detected. The examinations were offered at 1314 weeks gestation as part of routine maternal care and were done by specially trained midwives. The pregnancy outcomes were ascertained from obstetric and pediatric records, and the data were completed by information from the national birth and malformation registries.
RESULTS: A total of 307 fetuses (1.5%) with a major malformation were found; 67 fetuses (0.3%) had noncardiac major structural defects expected to be detectable by ultrasonography in early pregnancy. Thirty-five of 67 (52%) were identified at the early scan. Sensitivity for these defects increased from 22% to 79% from the first to the last (sixth) study year (P = 009).
CONCLUSION: In a low-risk population, adequate sensitivity in screening for major malformations by early ultrasonography can be achieved after a learning curve of 34 years.
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