| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
ORIGINAL RESEARCH |
From the Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, and Department of Radiology, University of Florida College of Medicine, Gainesville, Florida.
Address reprint requests to: Rodney K. Edwards, MD, MS, University of Florida College of Medicine, Department of Obstetrics and Gynecology, PO Box 100294, Gainesville, FL 32610-0294; E-mail: edwardsr{at}obgyn.ufl.edu.
OBJECTIVE: To assess whether the antibiotic chosen for intrapartum antibiotic prophylaxis affects the subsequent exposure of the neonate to ampicillin-resistant gram-negative bacteria.
METHODS: We performed a randomized clinical trial of ampicillin versus penicillin for intrapartum antibiotic prophylaxis. Genital tract cultures for Enterobacteriaceae were obtained at study entry and 8–36 hours postpartum. Organisms were isolated, identified, and tested for ampicillin susceptibility.
RESULTS: The ampicillin (n = 175) and penicillin (n = 177) groups, respectively, did not differ in rates of ampicillin-resistant Escherichia coli at entry (25% versus 22%, P = .57) or postpartum (36% versus 38%, P = .64). Similarly, groups did not differ in rates of ampicillin-resistant Enterobacteriaceae at entry (38% versus 32%, P = .23) or postpartum (51% versus 55%, P = .46). However, postpartum culture rates of resistant Escherichia coli were higher than entry culture rates for both the ampicillin (36% versus 25%, P = .026) and penicillin (38% versus 22%, P < .001) groups. Postpartum culture rates of resistant Enterobacteriaceae were also higher than entry culture rates for both the ampicillin (51% versus 38%, P < .001) and penicillin (55% versus 32%, P < .001) groups. Results were similar when considering only women who received two or more doses and no additional antibiotics.
CONCLUSION: Intrapartum antibiotic prophylaxis with either ampicillin or penicillin increases exposure of neonates to ampicillin-resistant Enterobacteriaceae.
This article has been cited by other articles:
|
|
 |
|
  R. K. Edwards and P. Duff Intrapartum Antibiotic Prophylaxis: Making an Evidence-Based Selection Pediatrics, January 1, 2006; 117(1): 255 - 256. [Full Text] [PDF]
|
|
|
|
|
|
T. S. Glasgow, P. C. Young, and C. L. Byington Intrapartum Antibiotic Prophylaxis: Making an Evidence-Based Selection: In Reply Pediatrics, January 1, 2006; 117(1): 256 - 257. [Full Text] [PDF]
|
|
|
|
|
|
T. S. Glasgow, P. C. Young, J. Wallin, C. Kwok, G. Stoddard, S. Firth, M. Samore, and C. L. Byington Association of Intrapartum Antibiotic Exposure and Late-Onset Serious Bacterial Infections in Infants Pediatrics, September 1, 2005; 116(3): 696 - 702. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Jaureguy, M. Carton, P. Panel, P. Foucaud, M.-J. Butel, and F. Doucet-Populaire Effects of Intrapartum Penicillin Prophylaxis on Intestinal Bacterial Colonization in Infants J. Clin. Microbiol., November 1, 2004; 42(11): 5184 - 5188. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Gibbs, S. Schrag, and A. Schuchat Perinatal Infections Due to Group B Streptococci Obstet. Gynecol., November 1, 2004; 104(5): 1062 - 1076. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Rentz, M. H. Samore, G. J. Stoddard, R. G. Faix, and C. L. Byington Risk Factors Associated With Ampicillin-Resistant Infection in Newborns in the Era of Group B Streptococcal Prophylaxis Arch Pediatr Adolesc Med, June 1, 2004; 158(6): 556 - 560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Scott 2002 Roy M. Pitkin Award Obstet. Gynecol., May 1, 2003; 101(5): 839 - 839. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
