| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
ORIGINAL RESEARCH |
From the Department of Obstetrics and Gynecology, University of Iowa College of Medicine, Iowa City, Iowa.
Address reprint requests to: Bradley J. Van Voorhis, MD, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242-1080; E-mail: brad-van-voorhis{at}uiowa.edu.
OBJECTIVE: To estimate the incidence and regression rates of uterine leiomyomata and polyps in a cohort of asymptomatic, premenopausal women.
METHODS: Saline infusion sonography was performed twice, 2.5 years apart, in a cohort of 64 initially asymptomatic women. Subjects completed a questionnaire that assessed the development of abnormal uterine bleeding.
RESULTS: The mean age of women (at second ultrasound) was 44 years. In four of seven women with polyps at the original ultrasound, their polyps regressed. Polyps that regressed tended to be smaller than polyps that persisted. Ten women had endometrial polyps at the second ultrasound for a point prevalence of 16% and a cumulative incidence rate of 12% per 2.5 years. A higher percentage of women with uterine polyps had complaints of abnormal uterine bleeding than women with no uterine abnormalities (70% versus 33%, P = .04). Six leiomyomata in four women were no longer detected in the second ultrasound. Leiomyomata that regressed were in older premenopausal women and were smaller than leiomyomata that persisted. The point prevalence and incidence rates of leiomyomata were 27% and 13% per 2.5 years, respectively. Leiomyomata grew an average of 1.2 cm per 2.5 years, but great variation in growth rates were noted.
CONCLUSION: Small uterine polyps frequently regressed spontaneously, whereas larger polyps were more likely to persist and were associated with the development of abnormal bleeding. Smaller leiomyomata in older premenopausal women also regressed whereas larger leiomyomata tended to grow while often remaining asymptomatic.
This article has been cited by other articles:
|
|
 |
|
  L. Pal, A. L. Niklaus, M. Kim, S. Pollack, and N. Santoro Heterogeneity in endometrial expression of aromatase in polyp-bearing uteri Hum. Reprod., January 1, 2008; 23(1): 80 - 84. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. M. Horne and D. L. Blithe Progesterone receptor modulators and the endometrium: changes and consequences Hum. Reprod. Update, November 1, 2007; 13(6): 567 - 580. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J L Hughes and J F Reidy Imaging and treatment of uterine fibroids including the role of uterine artery embolisation Imaging, June 1, 2003; 15(2): 79 - 88. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 ABSTRACTS Obstet. Gynecol., April 1, 2003; 101(4): 794 - 796. [Full Text] [PDF]
|
|
|
|
 |
|
 OTHER ARTICLES NOTED (Nov 01 to 18 Oct 02) Evid. Based Nurs., January 1, 2003; 6(1): e1 - 1. [Full Text] [PDF]
|
|
|
|
 |
|
 Natural History of Uterine Polyps and Leiomyomata Journal Watch Women's Health, September 24, 2002; 2002(924): 3 - 3. [Full Text]
|
|
|
|
 |
|
 Uterine Polyps and Fibroids Can Regress Without Treatment Journal Watch (General), July 30, 2002; 2002(730): 6 - 6. [Full Text]
|
|
|
|
|
|
D. S. Guzick So Many Studies, So Little Insight Obstet. Gynecol., July 1, 2002; 100(1): 1 - 2. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
