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Obstetrics & Gynecology 2002;100:140-144
© 2002 by The American College of Obstetricians and Gynecologists
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ORIGINAL RESEARCH

Inhibin-A Levels and Severity of Hypertensive Disorders Due to Pregnancy

Gerda G. Zeeman, MD, James M. Alexander, MD, Donald D. McIntire, PhD, William Byrd, PhD and Kenneth J. Leveno, MD

From the Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas.

Address reprint requests to: Gerda G. Zeeman, MD, University of Texas Southwestern Medical Center at Dallas, Department of Obstetrics and Gynecology, 5323 Harry Hines Boulevard, Dallas, TX 75390-9032; E-mail: gerda.zeeman{at}utsouthwestern.edu.

OBJECTIVE: To evaluate the use of 3rd trimester inhibin-A levels as an adjunct to assess severity of hypertensive disorders due to pregnancy in women evaluated for preeclampsia.

METHODS: Serum inhibin-A concentration was measured in a consecutive series of women evaluated for preeclampsia in the third trimester of pregnancy.

RESULTS: Inhibin-A levels were significantly associated with the severity of proteinuric hypertensive disease due to pregnancy. Women with gestational hypertension or those with chronic hypertension without superimposed preeclampsia had levels comparable with normotensive women. The sensitivity to detect proteinuric hypertension was 16%.

CONCLUSION: Although inhibin-A levels rise with increasing severity of disease, due to considerable overlap of normal and abnormal serum levels in women with and without preeclampsia, inhibin-A is not a useful adjunct for the classification of hypertensive disorders due to pregnancy.




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G. G. Zeeman, J. M. Alexander, D. D. McIntire, W. Byrd, and K. J. Leveno
Inhibin-A and Superimposed Preeclampsia in Women With Chronic Hypertension
Obstet. Gynecol., February 1, 2003; 101(2): 232 - 236.
[Abstract] [Full Text] [PDF]


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Copyright © 2002 by the American College of Obstetricians and Gynecologists.